Friday, May 17, 2013

An Imprisoned Hacker Invented an ATM Attachment That Stops Skimmers

Valentin Boanta has a lot of free time on his hands?five years worth, to be exact. That's because Boanta is currently serving a prison sentence for, according to Reuters, "supplying gadgets to an organized crime gang used to conceal ATM skimmers." So with all that time to think about what he's done, the apparently penitent prisoner spent six months developing an ATM add-on to prevent the exact crime that put him there in the first place.

Read more...

    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/0JqwSqhq0tA/an-imprisoned-hacker-invented-an-atm-attachment-that-st-508232101

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Parade permits allow radioactive waste moves

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Thursday, May 16, 2013

Is Beyonce Pregnant? Let's Look at the Evidence

Is Blue Ivy Carter going to be a big sister? This week, the rumor mill is buzzing with speculation that Beyonce may be pregnant with baby No. 2. Before we get too excited, let's remember that Mrs. Jay-Z has been the subject of many false pregnancy rumors over the years. Nevertheless, Beyonce has said that she "would like more children," so it's not outside the realm of possibility. Let's take a look at the 5 most compelling clues that Beyonce may be pregnant -- and take each with a grain of salt.

Source: http://www.ivillage.com/beyonce-pregnant-singer-cancels-concert-apologizes/1-a-536218?dst=iv%3AiVillage%3Abeyonce-pregnant-singer-cancels-concert-apologizes-536218

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New research shows what raises and lowers blood pressure: Cell phones, salt and saying om

New research shows what raises and lowers blood pressure: Cell phones, salt and saying om [ Back to EurekAlert! ] Public release date: 15-May-2013
[ | E-mail | Share Share ]

Contact: Valerie Kulbersh
vkulbersh@pollock-pr.com
212-941-1414
American Society for Hypertension, Inc.

Presented at the 28th Annual Scientific Meeting of the American Society of Hypertension

San Francisco, Calif. May 15, 2013 Considered the "silent killer," high blood pressure affects approximately one billion people worldwide, including one in three adults in the United States. From May 15 18, 2013, members of the medical community from across the globe gather at the 28th Annual Scientific Meeting of the American Society of Hypertension (ASH) in San Francisco to discuss the epidemic. During the conference, more than 200 new studies about hypertension will be shared, with the goal of increasing the understanding of hypertension and one day curing it altogether.

Among the findings from the ASH meeting is research that suggests mobile phone calls may cause a rise in blood pressure; yoga may lower it; and despite the need to cut back on sodium to lower blood pressure, hypertensive individuals may have an increased desire for saltier foods.

William B. White, MD, ASH President and 2013 Scientific Program Committee Chair adds, "The ASH meeting brings together the country's top scientists in clinical hypertension to give numerous state-of-the-art lectures on a wide variety of topics in hypertension and related clinical concerns."

Mobile Phone Calls Acutely Increase Blood Pressure

As of December 2012, 87% of American adults had a mobile phone1. According to a recent study from doctors G. Crippa; D. Zabzuni; A. Cassi; and E. Bravi of Guglielmo da Saliceto Hospital, talking on those mobile phones causes a significant rise in blood pressure. During a phone call, blood pressure readings jumped significantly from 121/77 to 129/82.

Systolic blood pressure rise was less drastic in patients who were used to participating in more than 30 phone calls per day. While the reason behind this is not known, Dr. Crippa speculates two possible reasons: "The subset of patients who were more accustomed to phone use were younger, which could show that younger people are less prone to be disturbed by telephone intrusions. Another possibility is that people who make more than 30 calls per day may feel more reassured if the mobile phone is activated since they are not running the risk of missing an opportunity."

Saying Om: Yoga Can Lower Blood Pressure

Yoga calms the mind and works out the body, but now, a study on the effects of yoga on hypertension concluded that yoga can significantly lower blood pressure. The 24-week study, conducted by Debbie L. Cohen, MD; Anne Bowler, BA and Raymond R. Townsend, MD of the University of Pennsylvania, showed that people who practiced yoga 2 3 times per week saw their blood pressure decrease significantly: an average of three points for both systolic and diastolic blood pressure, from 133/80 to 130/77. Participants who only followed a controlled dietand did not practice yogasaw only a decrease of one point, from 134/83 to 132/82.

Higher Salt Preference in Hypertensive People, but Using Other Seasonings Can Curb Desire

A new study shows that hypertensive individuals actually prefer more salt in their food than do normotensive individuals. The study of 44 adults aged 73.5 +/- 7.0 years was conducted by a team at Sao Paolo University in Brazil.

Initially, participants were given three pieces of bread with varying amounts of salt on each. In this tasting, 68% of hypertensive and 31% of normotensive patients (those with normal blood pressure levels) preferred the bread with the highest concentration of salt. Fifteen days later, the patients underwent an identical taste testthe only difference being that other seasonings had been added to the salted bread. In that case, only 14% of hypertensive and 0% of normotensive patients preferred the bread with the highest salt content. Not only did this show that hypertensive patients prefer a higher salt content, but that, across the board, use of other seasonings diminished the preference for salt.

Healthier Medical Practitioners Strive for Healthier Patients

Healthy lifestyle behaviors are associated with a reduced risk of hypertension in adultsbut a new study conducted by J. Fang, C. Ayala and F. Loustalot of the Centers for Disease Control (CDC) reveals that a primary care physician's (PCP) healthy lifestyle behaviors may be linked to his or her recommendations for hypertension prevention. The study looked at what percentage of physicians recommended one of six key healthy lifestyle recommendations for hypertension prevention: consume a healthy diet (89.4%); reduced salt intake (89.9%); attain or maintain a healthy weight (90.3%); limit alcohol intake (69.4%); be physically active (95.1%); and stop smoking (90.4%).

Fifty-six percent of practitioners recommended all six healthy habits. Of note, the probability of recommending all six lifestyle behaviors increased when PCPs engaged in regular physical activity or consumed the recommended amount of produce (five or more cups per day) for four or more days each weekshowing that a PCP's own behavior was associated with clinical recommendations to prevent hypertension for their adult patients.

###

About the American Society of Hypertension, Inc.

The American Society of Hypertension, Inc. (ASH) is the largest U.S. professional organization of scientific investigators and healthcare professionals committed to eliminating hypertension and its consequences. ASH is dedicated to promoting strategies to prevent hypertension and to improving the care of patients with hypertension and associated disorders. The specific focus of the Society is to translate current research findings on hypertension into effective treatment strategies, in order to better address the needs of hypertensive patients. For more information, please visit http://www.ash-us.org.

1 Pew Internet Post-Election Survey, November 14 December 09, 2012. N=2,261 adults ages 18+. Margin of error is +/- 2.3 percentage points.


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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


New research shows what raises and lowers blood pressure: Cell phones, salt and saying om [ Back to EurekAlert! ] Public release date: 15-May-2013
[ | E-mail | Share Share ]

Contact: Valerie Kulbersh
vkulbersh@pollock-pr.com
212-941-1414
American Society for Hypertension, Inc.

Presented at the 28th Annual Scientific Meeting of the American Society of Hypertension

San Francisco, Calif. May 15, 2013 Considered the "silent killer," high blood pressure affects approximately one billion people worldwide, including one in three adults in the United States. From May 15 18, 2013, members of the medical community from across the globe gather at the 28th Annual Scientific Meeting of the American Society of Hypertension (ASH) in San Francisco to discuss the epidemic. During the conference, more than 200 new studies about hypertension will be shared, with the goal of increasing the understanding of hypertension and one day curing it altogether.

Among the findings from the ASH meeting is research that suggests mobile phone calls may cause a rise in blood pressure; yoga may lower it; and despite the need to cut back on sodium to lower blood pressure, hypertensive individuals may have an increased desire for saltier foods.

William B. White, MD, ASH President and 2013 Scientific Program Committee Chair adds, "The ASH meeting brings together the country's top scientists in clinical hypertension to give numerous state-of-the-art lectures on a wide variety of topics in hypertension and related clinical concerns."

Mobile Phone Calls Acutely Increase Blood Pressure

As of December 2012, 87% of American adults had a mobile phone1. According to a recent study from doctors G. Crippa; D. Zabzuni; A. Cassi; and E. Bravi of Guglielmo da Saliceto Hospital, talking on those mobile phones causes a significant rise in blood pressure. During a phone call, blood pressure readings jumped significantly from 121/77 to 129/82.

Systolic blood pressure rise was less drastic in patients who were used to participating in more than 30 phone calls per day. While the reason behind this is not known, Dr. Crippa speculates two possible reasons: "The subset of patients who were more accustomed to phone use were younger, which could show that younger people are less prone to be disturbed by telephone intrusions. Another possibility is that people who make more than 30 calls per day may feel more reassured if the mobile phone is activated since they are not running the risk of missing an opportunity."

Saying Om: Yoga Can Lower Blood Pressure

Yoga calms the mind and works out the body, but now, a study on the effects of yoga on hypertension concluded that yoga can significantly lower blood pressure. The 24-week study, conducted by Debbie L. Cohen, MD; Anne Bowler, BA and Raymond R. Townsend, MD of the University of Pennsylvania, showed that people who practiced yoga 2 3 times per week saw their blood pressure decrease significantly: an average of three points for both systolic and diastolic blood pressure, from 133/80 to 130/77. Participants who only followed a controlled dietand did not practice yogasaw only a decrease of one point, from 134/83 to 132/82.

Higher Salt Preference in Hypertensive People, but Using Other Seasonings Can Curb Desire

A new study shows that hypertensive individuals actually prefer more salt in their food than do normotensive individuals. The study of 44 adults aged 73.5 +/- 7.0 years was conducted by a team at Sao Paolo University in Brazil.

Initially, participants were given three pieces of bread with varying amounts of salt on each. In this tasting, 68% of hypertensive and 31% of normotensive patients (those with normal blood pressure levels) preferred the bread with the highest concentration of salt. Fifteen days later, the patients underwent an identical taste testthe only difference being that other seasonings had been added to the salted bread. In that case, only 14% of hypertensive and 0% of normotensive patients preferred the bread with the highest salt content. Not only did this show that hypertensive patients prefer a higher salt content, but that, across the board, use of other seasonings diminished the preference for salt.

Healthier Medical Practitioners Strive for Healthier Patients

Healthy lifestyle behaviors are associated with a reduced risk of hypertension in adultsbut a new study conducted by J. Fang, C. Ayala and F. Loustalot of the Centers for Disease Control (CDC) reveals that a primary care physician's (PCP) healthy lifestyle behaviors may be linked to his or her recommendations for hypertension prevention. The study looked at what percentage of physicians recommended one of six key healthy lifestyle recommendations for hypertension prevention: consume a healthy diet (89.4%); reduced salt intake (89.9%); attain or maintain a healthy weight (90.3%); limit alcohol intake (69.4%); be physically active (95.1%); and stop smoking (90.4%).

Fifty-six percent of practitioners recommended all six healthy habits. Of note, the probability of recommending all six lifestyle behaviors increased when PCPs engaged in regular physical activity or consumed the recommended amount of produce (five or more cups per day) for four or more days each weekshowing that a PCP's own behavior was associated with clinical recommendations to prevent hypertension for their adult patients.

###

About the American Society of Hypertension, Inc.

The American Society of Hypertension, Inc. (ASH) is the largest U.S. professional organization of scientific investigators and healthcare professionals committed to eliminating hypertension and its consequences. ASH is dedicated to promoting strategies to prevent hypertension and to improving the care of patients with hypertension and associated disorders. The specific focus of the Society is to translate current research findings on hypertension into effective treatment strategies, in order to better address the needs of hypertensive patients. For more information, please visit http://www.ash-us.org.

1 Pew Internet Post-Election Survey, November 14 December 09, 2012. N=2,261 adults ages 18+. Margin of error is +/- 2.3 percentage points.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2013-05/pc-nrs051413.php

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A Chat With Daniel Guermeur, Founder Of Das Keyboard

4d9badc7c3de0a7f0235b5.L._V388056413_SX200_I've been enamored with the Das Keyboard since it launched in 2005. These supremely clicky, IBM-style keyboards are some of the most rugged mechanical input devices you can buy. Their Pro model -- an all-black monolith with black keys and no key markings -- is the gold standard for Gibson-esque console jockeys who believe that the best keyboard can be used as a weapon and shouldn't be touched by mere mortals. The company just launched a new "quiet" version of its Das Keyboard, Model S Professional Quiet, and I thought it would be fun to talk with Daniel Guermeur, founder of the company who went from being an open-source software maven at the turn of the century to making one of the most sought-after and coolest keyboards on the market. While Guermeur still works in software, his clicky Das Keyboard is probably his most lasting legacy in the gaming and programming world, a unique tool suited to unique professionals.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/qA78snC19Xg/

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Wednesday, May 15, 2013

Nokia unveils new metal-body Lumia smartphone

LONDON/HELSINKI (Reuters) - Nokia unveiled a lighter, metal model in its Lumia smartphone range, as it tries to catch the eye of buyers to close the huge market lead of rivals Samsung and Apple Inc in the lucrative handset market.

The Lumia 925, to be sold for 469 euros ($610) before taxes and subsidies through carriers such as Vodafone and China Mobile, is the latest in Nokia's range using Windows Phone software, on which Chief executive Stephen Elop has pinned the future of the loss-making company to reverse a dramatic drop in revenue over the last two years.

The phone weighs 139 grams, compared with 185 grams for the earlier 920 model, which some critics had said was too heavy.

The new phone will be rolled out globally starting in June, and is due to be sold in the United States by T-Mobile and in China by China Mobile and China Unicom, it said.

On Friday, Nokia unveiled the Lumia 928 for the U.S. market, priced at $99 after a rebate and a two-year deal with Verizon Wireless.

($1 = 0.7703 euros)

(Reporting by Brenda Goh and Ritsuko Ando; Editing by Will Waterman)

Source: http://news.yahoo.com/nokia-unveils-metal-body-lumia-smartphone-092503048.html

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Recon Instruments reveals Recon Jet, a sports HUD so bright it needs shades (video)

Recon Instruments reveals Recon Jet, a sports HUD that's so bright it need shades

We know Glass comes with some snap-on shades, which is no doubt great when casually vlogging in the sun. If you're heading down a mountain, though, you're going to need something a little more like Recon Jet. You may know Recon Instruments from its line of technolicious HUD ski goggles, but Jet sees the firm leap into more casual (yet no less useful) eyewear. Inside you'll find a dual-core processor, WiFi, GPS, Ant+, Bluetooth and an HD camera, plus all the sensors you could want (altimeter, thermometer, accelerometer etc). Recon Jet comes with its own open platform (which typically has been based on Android), and will have some existing native apps (video streaming, Facebook integration, etc.) on display at Google I/O this week. Comparison with Mountain View's own product will be inevitable, but we're guessing that Recon hopes you'll leave Glass on your desk, while popping Jet on for the weekend.

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Source: http://www.engadget.com/2013/05/15/recon-instruments-reveals-recon-jet/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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X-47B Completes a Carrier Takeoff

These robots grow up so fast. It was just two years ago that personnel at Naval Air Station?Patuxent River, Md. escorted PopMech through the lab, describing how they were making the X-47B jet fighter-sized drone ready to take off and land from a carrier. Today, the unmanned naval demonstration aircraft launched from the deck of George H.W. Bush, zipped around the carrier a few times, and flew itself back to Pax River.

Vice Adm. David Buss, commander of?Naval Air Forces?called the launch a "watershed event" in naval aviation.?"Today we saw a small but significant pixel in the future picture of our?Navy as we begin integration of unmanned systems into arguably the most?complex warfighting environment that exists today: the flight deck of a?nuclear-powered aircraft carrier," he said.

Taking off from the carrier is a milestone, but it requires only that the X-47B can handle the steam catapult launch, the same gear used by conventional Navy warplanes. Navy researchers were more interested to see how the unmanned aircraft behaved near the carrier, a complicated place for air traffic control that's full of different radio frequency emissions. The Navy says the testers "demonstrated the ability to precisely navigate the X-47B within the?controlled airspace around an aircraft carrier at sea and seamlessly pass?control of the air vehicle from a 'mission operator' aboard the carrier" to one located in?at NAS Patuxent River.

Over the next few weeks, the X-47B aircraft will fly several approaches to the?ship. This will lead up to the big show?landing this thing a?pitching flight deck. (The X-47B set down on land following this test.)

Landing on an aircraft carrier is one of the most difficult feats of aviation, requiring a clever mesh of man and machine. The Navy is building the X-47B's landing capability on technology pilots use today, the Precision Approach Landing System (PALS), but going beyond what it uses to help human aviators land on the deck. PALS uses SPN-46 radar to locate an aircraft in relation to a carrier.?However the PALS radar covers only the rear of the carrier and is limited by the number of aircraft it can track simultaneously. These deficiencies make it unsuitable for controlling UAVs that are approaching to land.

Instead, the Navy's robotic landing system relies on precise GPS coordinates to obtain 360-degree coverage and automate navigation. The airplane calculates the appropriate flight paths around the ship as the carrier supplies the vessel's speed, the sea state, and other data.

If the X-47B succeeds, it will not exactly open up a new chapter in naval aviation history?this is just a demonstration airplane?but it will blaze a trail for follow-up programs. Military strategists are keen on use of UAVs from carriers because these aircraft can stay overhead longer and launch from farther away. Those are good traits to have in an age of anti-ship missiles and other "access denial" strategies aimed at U.S. carrier groups. The ability to loiter in the air for long periods of time will also provide recon and intelligence-gathering possibilities that are vital for carrier operations, and give carrier-based planes the ability to?support friendly forces fighting on land.

Source: http://www.popularmechanics.com/technology/aviation/military/x-47b-uav-completes-a-carrier-takeoff-15470192?src=rss

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Tuesday, May 14, 2013

Pinterest for iPhone and iPad updated with push notifications for comments, likes, and repins

Pinterest for iPhone and iPad updated with push notifications for comments, likes, and repins

Pinterest for iPhone and iPad has been updated with a few new features including the ability to send a pin to someone (iPhone only) and push notifications for comments, likes, and repins, suggestions for search. You can also invite friends to pin with you on group boards, pin from the web, and mention your friends in comments.

Any Pinterest users out there? What do you think about this update? My favorite new feature is the ability to send a pin to someone -- been wanting to do that for awhile now, though I wish it was also supported for iPad.

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/NSMwHI6Kmu0/story01.htm

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Twitter buys Lucky Sort startup to help visualize your tweets

Twitter buys Lucky Sort to help visualize your tweets

Twitter just acquired Lucky Sort, a Portland, Oregon-based startup that built TopicWatch, a visualization and navigation engine known for presenting large amounts of data in an easy-to-digest format. With more than 200 million users in more than 160 countries, Twitter certainly has more than enough data to warrant the acquisition, which means hashtag infographics like the one above could be available for Twitter users in the near future. Fans of Lucky Sort's TopicWatch product, on the other hand, will have to find some other venue for their data fix, for the service is set to shutter in the months ahead. Shocking, we know.

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Via: TechCrunch

Source: Lucky Sort

Source: http://www.engadget.com/2013/05/13/twitter-buys-lucky-sort/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Minnesota legalizes gay marriage

By Mark Elkington MADRID, May 12 (Reuters) - Barcelona were turning their attentions to strengthening the squad for next season after second-placed Real Madrid drew 1-1 at Espanyol on Saturday, to gift them a fourth La Liga title in five years. Barca, who play at third-placed Atletico Madrid later on Sunday, have an unassailable lead in the table as Jose Mourinho's team trail them by seven points with only two games left to play. "There'll only be a few changes," Barcelona vice-president Josep Bartomeu told Barca TV. ...

Source: http://news.yahoo.com/blogs/ticket/minnesota-legalizes-gay-marriage-212923538.html

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Master regulator that drives majority of lymphoma discovered

May 13, 2013 ? A soon-to-be-tested class of drug inhibitors were predicted to help a limited number of patients with B-cell lymphomas with mutations affecting the EZH2 protein. However, a research team, led by investigators at Weill Cornell Medical College, now report that these agents may, in fact, help a much broader cross section of lymphoma patients.

The study, reported in Cancer Cell, found that the EZH2 protein the drug agents inhibited is a powerful regulatory molecule in B-cells, and a key driver of cancer in these immune cells.

The study's lead investigator, Weill Cornell Medical College's Dr. Ari Melnick, suggests that combining an EZH2 inhibitor with another related targeted therapy may offer a much improved treatment for follicular lymphoma, a cancer that currently has no cure, as well as a non-toxic alternative to chemotherapy for at least a third of diffuse large B-cell lymphomas. Because these two lymphomas account for 70 percent of adult lymphomas, Dr. Melnick believes the new therapy could potentially help a broad cross section of lymphoma patients.

"Our research indicates that these inhibitors will be remarkably effective. I am very optimistic," says Dr. Melnick, the Gebroe Professor of Hematology/Oncology, professor of medicine and director of the Raymond and Beverly Sackler Center for Biomedical and Physical Sciences at Weill Cornell. "Researchers had thought EZH2 inhibitors would only help patients with a mutation in their EZH2 gene, which represents a small subset of lymphoma patients. What we found is that a majority of lymphomas turn out to be dependent on normal EZH2, not just mutated EZH2."

Tumor Cells Depend on the EZH2 Master Regulator

The new study was aimed at understanding what normal as well as mutated EZH2 does within B-cells -- basic information that remained unknown despite more than a decade of research into the protein.

The role of B-cells (white blood cells known as B-lymphocytes) is to produce antibodies against invading microbes. What the researchers discovered is that EZH2 is required in order for the immune system to generate germinal center B-cells, which are the cells that make the most powerful type of antibodies.

Germinal center B-cells divide extremely quickly and try to create within them the high affinity antibodies that will be beneficial to fight off invading infections. This process happens constantly because of our exposure to microorganisms.

"Most B-cell lymphomas arise from germinal center B-cells -- germinal centers are the engine for formation of lymphomas," says Dr. Melnick. "The reason for this is because germinal center B-cells divide very, very quickly while at the same time mutating their antibody genes. Unfortunately, many other genes get mutated when this happens, which can eventually result in lymphoma formation."

It turns out that the behavior of germinal center B-cell is orchestrated by EZH2, Dr. Melnick discovered. "EZH2 is a master regulator protein that turns off the brakes that prevent cell division, so it allows cells to divide without stopping," he says.

EZH2 also has a second function, which Dr. Melnick calls "surprising and perhaps even more important. It prevents germinal cells from transitioning to antibody-secreting cells," he says. "Indeed, in the normal immune system EZH2 prevents B-cells from exiting germinal centers so that these cells can continue to undergo sustained rapid cell division, which continues until the immune system says to stop. Then EZH2 goes away, and B-cells can develop into antibody-secreting cells, which send antibodies into the circulation to fight off infection."

Interestingly, mutations of EZH2 cause it to be even more efficient at promoting germinal center B-cell division and permanently keep them locked in this behavior, Dr. Melnick says. But he adds that most lymphomas that are derived from germinal cell B-cells are dependent on EZH2, whether normal or mutated, to sustain growth.

"Germinal center cells absolutely require EZH2 and the lymphomas that arise from germinal center cells inherit that need regardless of whether they have mutations," Dr. Melnick says. "We discovered that it is not just the small percentage of patients with EZH2 mutations who are candidates for these inhibitors. It is actually most of the lymphomas that originate from germinal center B-cells -- and that represents the majority of patients."

The researchers report the development of a novel and highly specific EZH2 inhibitor, tested its effects against large panels of lymphoma cells and found that it works particularly well against germinal center-derived lymphomas regardless of whether or not they have EZH2 mutations.

"The case of EZH2 exemplifies a critically important emerging concept in cancer -- that tumor cells are dependent on the master regulators that are required to sustain the normal cell type from which they originate," Dr. Melnick adds.

According to researchers, another implication of the study is that it may be possible to combine an EZH2 inhibitor with a drug that targets BCL2, which is also in clinical testing, to achieve a more powerful synergistic effect.

"EZH2 and BCL2 mutations tend to occur together in germinal center derived lymphomas. In our report, we show that indeed these two genes cooperate to drive lymphoma formation from germinal center B-cells, and so a combination therapy that inhibits both genes might offer a very powerful therapy," says Dr. Melnick. "Indeed, combining EZH2 inhibitors and BCL2 inhibitors had a much greater effect in cells and in animal models of lymphomas than either drug alone." These results pave the way for translation of combinatorial-targeted therapy for patients with incurable lymphomas.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/QFGwZyW77ro/130513152838.htm

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Monday, May 13, 2013

Argentina faces very different debt default if loses legal fight

By Hilary Burke

BUENOS AIRES (Reuters) - When Argentina defaulted on its debt in 2002, the economy was collapsing and a bloody popular revolt had helped topple two presidents in a week. Now, the country could default again, but it would be over a matter of principle rather than necessity.

After a decade of sleepy litigation, investors got a jolt late last year when U.S. courts ruled in favor of "holdout" creditors who had rejected Argentine debt exchanges in 2005 and 2010 and sued to be repaid in full on their defaulted bonds.

A U.S. judge ordered Argentina to pay the holdouts the full $1.33 billion owed them the next time it serviced restructured debt. Argentina appealed, and a ruling by the 2nd U.S. Circuit Court of Appeals is expected in the coming weeks.

Investors are following the case closely because Argentina appears willing to enter into technical default in order to avoid paying the holdouts any more than other creditors received.

The nearly 93 percent of bondholders who accepted the debt exchanges got returns of as low as 25 cents on the dollar.

Tough-talking Argentine President Cristina Fernandez has pledged to keep paying the restructured debt but vows never to pay the "vultures" that bought the bonds at a steep discount and sued for full repayment.

When Argentina defaulted on some $100 billion in bonds 11 years ago, its debt represented 166 percent of gross domestic product. Bank deposits were frozen and devalued, the economy shrank 11 percent in one year, and millions lost their jobs.

Argentina's economy rebounded after that crisis and boomed during most of the last decade. Although growth slowed sharply in the last year and inflation is high, the debt burden is down to about 42 percent of GDP.

In other words, Argentina could pay the holdouts if it wanted, but it refuses to do so.

"Argentina will not blink and neither will the holdouts, so this will lead to a technical default," said Shahriar Shahida, co-founder of Constellation Capital Management LLC in New York, which is currently invested in Argentina and believes it would be unfair to favor the holdouts over exchange bondholders.

"This is an unparalleled case of somebody defaulting not because they don't have capacity, not because they don't have willingness, but because somebody is forcing them to do something egregious," he said.

MARKETS ON EDGE

Argentina says it will fight the holdouts - led in this case by Elliott Management affiliate NML Capital and Aurelius Capital Management - all the way to the U.S. Supreme Court.

Sources familiar with the position of Elliott and Aurelius say Argentina has never shown a willingness to negotiate.

Investors anticipate the country will eventually defy U.S. courts if they insist the holdouts be paid in full.

In that scenario, Argentina is widely expected to force a technical default on the restructured bonds issued under New York law - which would be most directly affected by the rulings - while trying to create a new payment scheme for those bonds.

One option would be a swap in which the exchange bondholders turned in their New York paper for new Argentine-law bonds. Some analysts warn that might not be doable, however.

The default would be technical because Argentina might try to pay the exchange bondholders without paying the holdouts, and the courts could then disrupt the payments. Or the country could suspend payments on the restructured bonds citing its own laws, which bar it from paying the holdouts on better terms.

Argentine economic officials have refused to discuss whether they are evaluating a "Plan B" for payments. The next interest payments on restructured bonds come due June 2 and June 30.

When the court rulings first came down last year, many investors scrambled to sell off their Argentine bonds and some firms specializing in distressed debt moved in to buy.

The market has since stabilized and the restructured bonds regained some ground in April. Argentina's Global 2017, issued during the 2010 debt swap, is now yielding around 16.3 percent, down from 19.6 percent in early March.

In terms of credit default swap contracts - which act as insurance against a default - the maximum payout possible dropped sharply in late 2012 and now stands at about $1.53 billion, data from the Depository Trust & Clearing Corp shows.

CDS payouts would likely be less, however, after an auction process to determine the recovery value of the defaulted bonds.

Ultimately, Argentina is no longer as relevant to global credit markets as it used to be. It has not issued international debt since the 2002 default and its weighting on the JPMorgan Chase EMBI+ emerging market sovereign bond index has shrunk to 1.8 percent from over 23 percent in early 2001.

Capital controls and more-recent foreign currency restrictions have further isolated the country, which is seen as an anomaly in largely market-friendly Latin America.

Credit Suisse analysts said last week that most of their contacts in Buenos Aires believe the spillover effects of a technical default "would be relatively small due to Argentina's relative isolation from international capital markets and the ongoing deterioration in Argentina's business climate."

LEGAL OUTLOOK

In November, U.S. District Judge Thomas Griesa ordered Argentina to deposit the $1.33 billion owed to holdouts in an escrow account by December 15, when restructured debt came due.

He also required that third parties involved in payments on Argentina's restructured bonds be held accountable if the court order were evaded. This included Bank of New York Mellon Corp, which acts as trustee for the exchange bondholders.

The 2nd Circuit suspended these orders under an emergency judicial stay while reviewing Argentina's appeal.

It is not clear, however, that the stay would remain in place if Argentina had to appeal to the Supreme Court. Most analysts seem to think it would, but there is no guarantee.

It is also anyone's bet how the 2nd Circuit will rule. The court upheld Griesa's original decision, finding Argentina had discriminated against the holdouts and violated the "pari passu" or equal treatment clause in their defaulted bond contracts.

But with the U.S. government arguing Griesa's rulings could complicate future sovereign debt restructurings, the 2nd Circuit may seek to limit the scope of the payment orders.

The appeals court asked Argentina to submit its own payment proposal, which essentially echoed the terms of the 2010 swap. NML and Aurelius rejected this outright.

If Argentina appealed to the Supreme Court and its case were accepted for review, a ruling could be made as late as June 2015, according to Bank of America Merrill Lynch analysts.

A new Argentine default, no matter how short-lived, would tend to push bond prices lower and hurt the balance sheets of local banks, which hold lots of debt. But most economists do not think there would be massive fallout, in part because Argentine exporters are much less reliant on trade finance than in 2002.

Guillermo Nielsen, who as finance secretary helped push through Argentina's tough debt restructuring in 2005, said nonetheless a default should be avoided at all costs.

"The New York financial market is important not only for less developed countries but also for developed countries. Even Sweden issues debt in the New York market," Nielsen said. "And here we have everything to be made, to be built, to be created. We need that financing."

(Additional reporting by Daniel Bases in New York and Alejandro Lifschitz and Guido Nejamkis in Buenos Aires; Editing by Kieran Murray, Bernard Orr)

Source: http://news.yahoo.com/argentina-faces-very-different-debt-default-loses-legal-110556026.html

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Philly abortion doctor guilty in 3 babies' deaths

FILE - In this March 8, 2010 file photo, Dr. Kermit Gosnell is seen during an interview with the Philadelphia Daily News at his attorney's office in Philadelphia. Gosnell was found guilty Monday, May 13, 2013 of found guilty of first-degree murder in the deaths of three babies born alive but acquitted in the death of a fourth baby. Gosnell was also found guilty of involuntary manslaughter in the overdose death of a patient. (AP Photo/Philadelphia Daily News, Yong Kim, File) MANDATORY CREDIT, NO SALES

FILE - In this March 8, 2010 file photo, Dr. Kermit Gosnell is seen during an interview with the Philadelphia Daily News at his attorney's office in Philadelphia. Gosnell was found guilty Monday, May 13, 2013 of found guilty of first-degree murder in the deaths of three babies born alive but acquitted in the death of a fourth baby. Gosnell was also found guilty of involuntary manslaughter in the overdose death of a patient. (AP Photo/Philadelphia Daily News, Yong Kim, File) MANDATORY CREDIT, NO SALES

Jack McMahon, the defense attorney for abortion doctor Kermit Gosnell, leaves the courthouse in Philadelphia Monday, May 13, 2013. Gosnell was found guilty Monday of first-degree murder in the deaths of three babies who authorities say were delivered alive and then killed with scissors at his grimy clinic. He was also found guilty of involuntary manslaughter in the drug-overdose death of a patient who had undergone an abortion. (AP Photo/Matt Rourke)

(AP) ? An abortion doctor was convicted Monday of first-degree murder and could face execution in the deaths of three babies who were delivered alive and then killed with scissors at his grimy, "house of horrors" clinic.

In a case that became a grisly flashpoint in the nation's abortion debate, Dr. Kermit Gosnell, 72, was also found guilty of involuntary manslaughter in the overdose death of an abortion patient. He was cleared in the death of a fourth baby, who prosecutors say let out a whimper before the doctor cut the spinal cord.

Gosnell, who portrayed himself as an advocate for poor and desperate women in an impoverished West Philadelphia neighborhood, appeared hopeful before the verdict was read and calm afterward.

The jury reached its verdict on its 10th day of deliberations. It will return May 21 to hear evidence on whether Gosnell should get the death penalty.

Gosnell attorney Jack McMahon called it a "very difficult case" to defend and said there was "a little bit of feeling on the defense part of what salmon must feel swimming upstream."

"There's a lot of emotion. You have the baby factor, which is a big problem. The media has been overwhelmingly against him," he said. But noting that Gosnell was cleared on some of the charges, McMahon said the jurors "obviously took their job seriously."

Prosecutors looked elated, but District Attorney Seth Williams declined comment until after the sentencing phase, citing a gag order.

Former clinic employees testified that Gosnell routinely performed illegal abortions past Pennsylvania's 24-week limit, that he delivered babies who were still moving, whimpering or breathing, and that he and his assistants dispatched the newborns by "snipping" their spines, as he referred to it.

"Are you human?" prosecutor Ed Cameron snarled during closing arguments. "To med these women up and stick knives in the backs of babies?"

Gosnell was also convicted of infanticide, racketeering and more than 200 counts of violating Pennsylvania's abortion laws by performing third-term abortions or failing to counsel women 24 hours in advance. The courtroom was locked for more than 30 minutes as the verdicts were read and the jurors polled one by one.

His co-defendant, former clinic employee Eileen O'Neill, was convicted of taking part in a corrupt organization and illegally billing for her services as if she were a licensed doctor.

The jury foreman let out big sigh before the verdicts were read and looked stressed. Another juror was seen crying.

The gruesome details came out more than two years ago during an investigation of prescription drug trafficking at Gosnell's clinic. Investigators said it was a foul-smelling "house of horrors" with bags and bottles of fetuses, including jars of severed feet, along with bloodstained furniture, dirty medical instruments, and cats roaming the premises.

Pennsylvania authorities had failed to conduct routine inspections of all its abortion clinics for 15 years by the time Gosnell's facility was raided. In the scandal's aftermath, two top state health officials were fired, and Pennsylvania imposed tougher rules for clinics.

Four former clinic employees pleaded guilty to murder and four more to other charges. They include Gosnell's wife, Pearl, a cosmetologist who helped perform abortions.

Both sides in the highly charged abortion debate endorsed the verdict.

"This has helped more people realize what abortion is really about," said David O'Steen, executive director of the National Right to Life Committee. He said he hopes the case results in more states passing bills that prohibit abortion "once the unborn child can feel pain."

Supporters of legalized abortion said the case was a preview of what poor, desperate young women could face if abortion is driven underground with more restrictive laws.

"Kermit Gosnell has been found guilty and will get what he deserves. Now, let's make sure these women are vindicated by delivering what all women deserve: access to the full range of health services including safe, high-quality and legal abortion care," said Ilyse G. Hogue, president of NARAL Pro-Choice America.

Midway through the six-week trial, anti-abortion activists accused the mainstream media of deliberately ignoring the case. Major news organizations denied it, though a number promptly sent reporters to cover the trial. About 30 reporters were in court for the verdict.

After prosecutors rested their five-week case, Common Pleas Judge Jeffrey Minehart threw out for lack of evidence three of seven murder counts involving aborted fetuses. That left the jury to weigh charges involving fetuses identified as Baby A, Baby C, Baby D and Baby E.

Prosecution experts said one was nearly 30 weeks along when the abortion took place, and was so big that Gosnell allegedly joked the baby could "walk to the bus." A second baby was said to be alive for about 20 minutes before a clinic worker snipped the neck. A third was born in a toilet and was moving before another clinic employee severed the spinal cord, according to testimony.

Baby E let out a whimper before Gosnell cut the neck, prosecutors alleged. Gosnell was acquitted in that baby's death, the only one of the four in which no one testified to seeing the baby killed.

Gosnell's attorney argued that none of the fetuses was born alive and that any movements were posthumous twitching or spasms.

Gosnell did not testify, and his lawyer called no witnesses in his defense. But McMahon branded prosecutors "elitist" and "racist" for pursuing his client, who is black and whose patients were mostly poor minorities.

"I wanted to be an effective, positive force in the minority community," Gosnell told The Philadelphia Daily News in a 2010 interview. "I believe in the long term I will be vindicated."

The defense also contended that the 2009 death of 41-year-old Karnamaya Mongar of Woodbridge, Va., a Bhutanese immigrant who had been given repeated doses of Demerol and other powerful drugs to sedate her and induce labor, was caused by unforeseen complications and did not amount to murder, as prosecutors charged.

Bernard Smalley, a lawyer for the woman's family, said he now hopes to bring "some sense of justice and quiet to this family that's been through so much."

Gosnell still faces federal drug charges. Authorities said that he ranked third in the state for OxyContin prescriptions and that he left blank prescription pads at his office and let staff members make them out to cash-paying patients.

He performed thousands of abortions over a 30-year career, some on patients as young as 13. Authorities said the medical practice alone netted him about $1.8 million a year, much of it in cash. Authorities found $250,000 hidden in a bedroom when they searched his house. Gosnell also owned a beach home and several rental properties.

"He created an assembly line with no regard for these women whatsoever," Cameron said. "And he made money doing that."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-05-13-Abortion%20Clinic%20Deaths/id-263824f000be4722982480425cafa695

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Sunday, May 12, 2013

Chris Brown and Rihanna Get NASTY ... on Twitter!

Source: http://www.thehollywoodgossip.com/2013/05/chris-brown-and-rihanna-get-nasty-on-twitter/

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Spacewalkers hunt for leak on International Space Station

Astronauts Thomas Marshburn and Christopher Cassidy are in the middle of a spacewalk to fix an ammonia leak. But after two hours of work Saturday, the astronauts didn't find any evidence of a leak in the pump.

By David Clark Scott,?Staff writer / May 11, 2013

The gloved hands of one of two astronauts working to replace a possible faulty pump on the International Space Station that was leaking ammonia.

NASA screenshot

Enlarge

Two hours into an unplanned spacewalk Saturday morning, the two astronauts have not found the source of ammonia coolant leak on the International Space Station.

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Astronauts Thomas Marshburn and Christopher Cassidy began their spacewalk at 8:44 a.m. Saturday. The two successfully removed a 60-pound pump box which NASA suspected was the source of the leaking ammonia coolant. But they found no evidence of the frozen ammonia flakes that had originally led them to the pump box.

The astronauts also found no evidence of damage to the box.

The walk was hastily planned after ISS crew members alerted Mission Control about the leak on Thursday when they spotted "snowflakes" of frozen ammonia floating near the pump box. NASA says that it has been aware of a slow ammonia leak, but the rate had jump to 5 pounds per day on Thursday.

The ammonia coursing through the plumbing is used to cool the space station's electronic equipment, according to the Associated Press. There are eight of these power channels, and all seven others were operating normally. As a result, life for the six space station residents was pretty much unaffected.

NASA's space station program manager Mike Suffredini said it's a mystery as to why the leak erupted on Thursday. One possibility is a micrometeorite strike.

By 11 a.m. Saturday, Cassidy and Marshburn were working to remove a nearby spare pump and drop it in the location where the suspected pump box was removed. The two men? are experienced spacewalkers: this is their fourth working sojourn outside the space station.

If the pump isn't the source of the leak, NASA's hunt for the source will continue. But that will be another crew's problem. Mashburn and Canadian commander, Chris Hadfield, are scheduled to head back to Earth on Monday.

But as the two men worked, there were the occasional moments when they could pause to look at the view 255 miles above the Earth. "Did you see the moon? Oh my God! Burn that in your memory, said Cassidy.

After running through a system check, the following exchange was heard:

"Houston, if you're still there, I'm feelin great," said Cassidy.

"We're still there. Copy that on feelin great," responded Mike Fincke, an astronaut who was guiding the duo from NASA's Johnson Space Center in Houston.

NASA is broadcasting the spacewalk live on its website.

Source: http://rss.csmonitor.com/~r/feeds/science/~3/gWkiX1FlfBw/Spacewalkers-hunt-for-leak-on-International-Space-Station

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Gwyneth Paltrow: Fashion Fail Month

  Wow. Score one for the cast and crew of the new Star Trek movie! The picture above on the right looks like an outfit that would be worn at a gala on the Starship Enterprise. How ridiculous. Sheer with cut off sleeves? Now we’re losing our minds on this one. The worst part is that she was named the most beautiful woman in the world recently. I guess that title has nothing to do with style choices, because this is just plain silly. The outfit on the above right picture looks like the wrapping materials someone would use for a big Valentine’s Day gift. It looks like she got it snagged on the way through the door, then had her assistant cut a strip off the make it look better. She needs to hurry up and fire her stylist so she doesn’t end up losing her title. It’s that bad. Your thoughts?   Pictures: PR Photos

Source: http://feedproxy.google.com/~r/RightCelebrity/~3/nLFz_HTaSY4/

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MLB suspends, fines umps after 2nd mistake

NEW YORK (AP) ? Major League Baseball suspended umpire Fieldin Culbreth for two games on Friday because he was in charge of the crew that allowed Astros manager Bo Porter to improperly switch relievers in the middle of an inning.

Culbreth and the rest of his crew ? Brian O'Nora, Bill Welke and Adrian Johnson ? were also fined an undisclosed amount after MLB admitted its umps goofed for the second straight day.

"The rule covering pitching changes was not applied correctly by the umpiring crew," MLB said in a statement.

Culbreth and his crew worked the Padres-Rays game in Tampa, Fla., on Friday night.

He told a pool reporter after the game that he takes "all the responsibility" for what happened.

As for the discipline?

"I look at it that baseball has high standards for their umpires and I have high standards for myself and I didn't meet those standards last night, so I am absolutely OK with everything," he said.

The problem in Houston came a day after Angel Hernandez and his crew in Cleveland failed to reverse a clear-cut home run after looking at a video review. MLB executive vice president Joe Torre said the umpires made an "improper call."

Hernandez was booed when the umpires were introduced Friday night before the Washington Nationals hosted the Chicago Cubs.

It's recently been a rough run for umps. Crew chief Tom Hallion was fined earlier this month after getting into a verbal spat with Tampa Bay pitcher David Price.

The latest trouble occurred in the seventh inning at Minute Maid Park. And while baseball does have video replay for some hard-to-tell calls ? and has talked for a couple of years about expanding its scope ? there was no mistaking what umpires saw.

With two outs and the Astros ahead 5-3, Houston reliever Wesley Wright came in from the bullpen and threw several warmup pitches from the mound. Porter, a first-year manager, then ran onto the field to stop him and brought in another reliever, Hector Ambriz.

Angels manager Mike Scioscia argued, correctly contending Wright was required to pitch to at least one batter. But the umpires permitted Ambriz to stay in and Scioscia put the game under protest ? it became moot when the Angels rallied to win 6-5.

Scioscia wasn't surprised by MLB's stern ruling.

"One thing I have found is that in the course of, especially with Joe Torre and Major League Baseball, that I think there is accountability," he said Friday in Chicago. "That might not always show its face but I know behind the scenes it's there and this is one example."

Pinch-hitter Luis Jimenez was on deck when Wright entered. Once Ambriz took over, Scott Cousins came up as a pinch-hitter.

On Friday, Porter was upset that he caused the problem.

"Personally, I want to apologize to their whole crew for putting them in that position," he said. "It's unfortunate for the game of baseball."

A day later, Culbreth tried to explain what happened.

"We just got to cross-sectioning different rules within the changing of a pitcher, and just had a hard time getting back on track from that," he said. "We got confused."

Porter said he spoke with Culbreth after the game and apologized to him when he realized he was wrong. But he still wanted to make a public apology.

"There are some repercussions, and again as I sit here today, it's more that I feel sorry for the crew chief and the crew for having to wear what it is that happened last night," Porter said.

Culbreth said Porter's mistake was not the problem.

"I look at it that the players and the managers, they go out and play the game and it is our job, whether they are knowingly or unknowingly getting outside the boundaries to get them back in, and I fell short of keeping them inside those lines," Culbreth said. "And that falls on me."

Wright, one of the pitchers involved in the fiasco, thinks it's unfortunate that Culbreth was suspended. He said when it happened; he figured he was going to have to stay in to face a batter.

"When they told me I was out of the game I was just kind of like: 'Maybe I don't understand the rule,'" he said. "It was just one of those weird situations."

A day earlier, a mistake in Cleveland caused a lot of commotion.

Adam Rosales and the Athletics were certain he'd hit a game-tying home run in the ninth inning against the Indians. Three umpires went to a video review and instead upheld the original call on the field that the ball didn't clear the left-field wall.

Oakland manager Bob Melvin was ejected and was later contacted by MLB officials.

The mistake drew attention all over the majors. Pittsburgh manager Clint Hurdle said he'd never before seen an obvious miss despite replay.

"This is the first one where there definitely is a line drawn where you go, 'Wow,'" he said.

_____

AP Sports Writers Kristie Rieken in Houston and Fred Goodall in Tampa, Fla., contributed to this story.

Source: http://news.yahoo.com/mlb-suspends-fines-umps-2nd-mistake-213728747.html

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Republicans slam IRS on 'Tea Party' targeting

By Patrick Temple-West and Susan Heavey

WASHINGTON (Reuters) - Republican lawmakers blasted the Internal Revenue Service on Friday after a top IRS official apologized for "inappropriate" targeting by the agency of applications for tax-exempt status from conservative political groups.

In a practice that conservatives complained about during the 2012 election campaign, organizations that used the words "patriots" or "Tea Party" in their tax-exempt status filings were flagged by the IRS for further review.

Lois Lerner, director of the IRS tax-exempt office, said the practice "was absolutely incorrect and it was inappropriate."

Speaking at an American Bar Association conference in Washington, Lerner said, "We would like to apologize for that."

None of the groups that were given extra scrutiny have been rejected yet for tax-exempt status, she said.

Lerner said the screening process was "absolutely not" influenced by anyone in the Obama administration.

Senate Republican Leader Mitch McConnell immediately called for a White House review to assure that "thuggish practices" were not being used by the government against Americans.

House Oversight and Government Reform Committee Chairman Darrell Issa, who earlier called for the IRS inspector general to look into allegations, said his committee will "aggressively follow up ... and hold responsible officials accountable."

Republican Senator Rob Portman in a statement accused the IRS of "overt and excessive harassment of groups targeted for their political beliefs" and urged "additional safeguards ... to prevent this obtrusive behavior in the future."

Tax-exempt applications, for groups ranging from hospitals to labor unions, are routinely reviewed by IRS civil servants.

Known as 501(c)(4) groups after the section of the tax code that makes them tax-exempt, such organizations can collect money from anonymous donors and spend it on advertising. To stay tax-exempt, they cannot endorse a candidate or a political party.

The number of groups seeking 501(c)(4) status has jumped since the U.S. Supreme Court's 2010 "Citizens United" decision that lifted government limits on corporate spending in federal elections.

Such contributions became controversial during the 2012 election season, as groups favoring both major political parties financed negative ad campaigns to try to influence the race between Obama and Republican challenger Mitt Romney.

"I will be discussing this further with the head of the IRS and expect a full briefing and report as to how this happened," said Republican Senator Orrin Hatch in a statement.

(Reporting by Patrick Temple-West and Susan Heavey; Editing by Kevin Drawbaugh, Fred Barbash and Philip Barbara)

Source: http://news.yahoo.com/u-tax-agency-admits-scrutiny-conservative-groups-wrong-174755076.html

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